Abstract

It is qenerally accepted that high oxygen tension in local wounds accelerate the activity of fibroblast which is an essential component for wound healing. In the present study. wound infection were made In rats using four standard inocular of streptococcus aureus (3.0X108) injected into subcutaneous wounds. The inoculation was done on the day of stripping, a 2X2 cm2 area of the dorsal skin from the rat. One uninoculated wound served as a control in each group. We directly measured the wound size by computer digitizer and the wound oxygen tension using Oxymeter, after applying a 1% povidone-iodone solution soaking (Group II), local TCDO applicafion (Group Ⅲ) fwice a day in each groups and using a hyperbaric chamber conditioned by 2.4 ATA for 90 minutes (Group Ⅳ). Also, we cultured the infected wounds and counted the colony numbers, after three day``s inoculation in each groups (×10(-2）). We found that the rate of wound healing and the tissue P02 in Group Ⅲ were very high, compared to the other groups The colony counts from the infected wound was high only in Group Ⅳ Also, culture counts were significantly low in the plasma with TCDO group .