Treatment of Partial Thickness Skin Defect with Cultured Allogenic Keratinocytes (Kaloderm.)

Seo,  Sang Won; Chang,  Choong Hyun; Cho,  Min Su; Hong,  Yoon Gi; Jeon,  Sae Wha

Original Article

Journal of the Korean Society of Traumatology 2007;20(1):1-5.

Sang Won Seo, Choong Hyun Chang, Min Su Cho, Yoon Gi Hong, Sae Wha Jeon

¹Department of Plastic and Reconstructive Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. hipson21@dreamwiz.com
²Tego Science Inc., Seoul, Korea.

동종유래각질세포(Cultured Allogenic Keratinocytes, Kaloderm)를 이용한 부분층 피부 결손의 치료

서상원·장충현·조민수·홍윤기·전세화*

성균관대학교 의과대학 강북삼성병원 성형외과학교실, 테고 사이언스?*

Abstract

PURPOSE
Grafting with autograft skin remains the most effective method for treating skin defects. When insufficient donor sites are present or patients are afraid of the operation, a skin graft is impossible. Cultured allogenic keratinocytes speed wound healing by providing cover and by producing growth factors and extracellular matrix protein. We report an application of cultured allogenic keratinocytes (Kaloderm., Tegoscience, Seoul, Korea) in the treatment of an acute partial thickness skin defect.
METHODS
From March 2005 to January 2006, 20 patients with a partial thickness skin defect were treated with cultured allogenic keratinocytes. The wound was covered with a sheet of cultured allogenic keratinocytes and ointment with Bactigras. gauze. The wound was inspected every two or three days. We regarded completion of epithelialization as wound healing.
RESULTS
The mean period between time of injury and time of Kaloderm. application was 7.5 days. The time taken from application of Kaloderm. to complete closure of the wounds was 7.2 days.
CONCLUSION
In view of the favorable outcome, cultured allogenic keratinocytes are safe and effective biologic dressing materials for use in the treatment of open wounds.

Key Words: Cultured allogenic keratinocyte; Partial thickness wound