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Journal of the Korean Society of Traumatology 2005;18(2):87-93.
Bone Mineral Bensity and Bone Turnover Marke rs in Patients with Femur Fracture Who Visited the Emergency Department
Kyoung Mi Lee, M.D., Seung Baik Han, M.D., Jun Sig Kim, M.D., Kwang Je Baek, M.D., Seong Bin Hong, M.D.*, Kyoung Ho Moon, M.D.**, Joon Soon Kang, M.D.**, Seong-Hwan Yoon, M.D.***
Department of Emergency Medicine, Department of Internal Medicine*
Department of Orthopedics*

Department of Neurosurgery*
College of Medicine, Inha University, Incheon, Korea
응급센터를 내원한 대퇴골 골절 환자에서 골밀도와
생화학적 표지자들의 의의
이경미·한승백·김준식·백광제·홍성빈*·문경호* *·강준순* *·윤승환* * *
인하대학교 의과대학 응급의학교실, 내과학교실*
신경외과학교실* * *
Backgound: The most frequent fracture seen at the emergency department (ED) in the elderly is a femur fracture whereas they do not know the degree of osteoporosis. We analyzed the degree of osteoporosis in patients with femur fractures and compared patients with only femur fractures (FX) to patients with femur and vertebral fractures (VX) by examining the clinical features, the bone mineral density (BMD), and biochemical markers. Methods: From January 2004 to December 2004, we enrolled prospectively 30 femur fracture patients who visited the ED. The bone mineral densities of the lumbar spine and the femur were examined. Total calcium, phosphate, alkaline phosphatase, osteocalcin, and serum C-terminal telopeptide (s-CTx) were measured. The patients with femur fractures were divided into two subgroups according to the presence of vertebral fracture. Results: All BMDs of the FX group showed osteoporosis. The s-CTx levels were higher than normal. The patients in the FX with VX were older than those in the FX only group, and had lower BMDs. There were no significant differences in markers between the subgroups, but the incidence of trochanteric fractures was higher in FX with VX group than in the FX only group. Conclusion: Femur fractures in the elderly were associated with osteoporosis. In our study, despite a considerable
difference in BMD between patients with femur fractures and those with femur fractures combined with vertebral fractures, there was no difference in biochemical markers on bone formation nor in the those of bone resorption. We will further investigate the biochemical markers and BMD in the population of osteoporotic fractures. So those indicators should be helpful for planning treatment and for prevention of FX in the elderly.
Key Words: Femur fracture; Osteoporosis; Bone mineral density


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