A 67-year-old woman had a traffic accident, and cardiac arrest was noted at the accident scene and at a local hospital with return of spontaneous circulation (ROSC) after 7 and 14 minutes of cardiopulmonary resuscitation (CPR), respectively. Upon arrival from the local hospital, she was comatose and intubated, her pupils were 4 mm in size and fixed, and her vital signs were as follows: blood pressure, 79/64 mmHg; pulse rate, 128 bpm; and body temperature, 36.0°C. Focused Assessment with Sonography for Trauma (FAST) did not show the lung sliding sign in the right hemithorax or intra-abdominal fluid collection. A lateral-view radiograph of the cervical spine revealed suspected atlanto-occipital dislocation (AOD) (Fig. 1A). Computed tomography (CT) at the local hospital showed grade I spleen contusion, retroperitoneal hematoma around the left kidney, multiple rib fractures with hemopneumothorax in the right hemithorax, and AOD with a 25-mm basion-dental interval (BDI) and prevertebral hematoma (Fig. 1B). Despite volume resuscitation with crystalloid and blood transfusions, hypotension with a systolic blood pressure (SBP) less than 70 mmHg persisted. Therefore, Zone I REBOA using a 7-Fr balloon catheter (RESCUE Balloon^TM, Tokai Medical Products, Aichi, Japan) was performed (Fig. 1C), and her blood pressure increased temporarily and then decreased despite 40-mL full balloon inflation and high-dose vasopressor infusion. Cardiac arrest recurred 8 minutes after balloon inflation, and ROSC was not achieved in 36 minutes of CPR.

A 58-year-old man sustained blunt trauma from an 8-m fall. His Glasgow Coma Scale score was 3. His pupils had a size of 6 mm on light reflex and were fixed. Upon arrival, his blood pressure and pulse rate were 98/60 mmHg and 92 bpm respectively, and he had multiple facial abrasions. FAST showed no intraabdominal fluid collection, but 20-minute serial FAST showed a small amount of fluid in the Morison pouch and perisplenic space. A CT scan revealed subdural hematoma (SDH) in the right hemisphere with a vague boundary between white and gray matter consistent with brain edema (Fig. 2A), multiple rib fractures, and central inframesocolic retroperitoneal hematoma in the para-aortic area beneath the left renal vein with small fluid collection in the abdominal cavity (Fig. 2B). After the CT scan, the patient became hemodynamically unstable with a blood pressure of 61/38 mmHg and a pulse rate of 91 bpm. Zone I REBOA was then performed using a RESCUE Balloon^TM (Fig. 2C). Following balloon inflation with 15 mL of saline, his blood pressure and pulse rate increased to 101/60 mmHg and 112 bpm, respectively. Simultaneous craniectomy and laparotomy were then performed. A central inframesocolic retroperitoneal hematoma and superficial liver and spleen lacerations with a small intraperitoneal hematoma were found during crash laparotomy. As the retroperitoneal hematoma was approached and controlled by midline infrarenal aortic exposure, it was possible to complete weaning from REBOA. However, the bleeding from the liver and spleen lacerations were not easily controlled even though the injuries were minor. During laparotomy, the SDH was evacuated and severe brain edema was observed by craniectomy. Since the brain injury was virtually irreversible, both surgical procedures were finished without further steps, and laparotomy was finished with temporary abdominal closure. Postoperatively, the patient remained hemodynamically unstable despite volume resuscitation and high-dose vasopressor infusion, and he died 341 minutes after arrival.

A 72-year-old man was admitted after a motorcycle accident. Upon arrival, he was comatose, and his pupils were 3 mm in size and fixed. He had a blood pressure of 71/54 mmHg, a pulse rate of 120 bpm, a respiratory rate of 12 breaths/minutes, and a hemoglobin level of 9.5 g/dL. He had multiple facial lacerations and cerebrospinal fluid leakage from the nose and left ear. FAST did not initially show intra-abdominal fluid collection, but 10-minute serial FAST showed a small amount of fluid in the splenorenal recess. Since the patient responded to volume resuscitation, he could undergo imaging evaluation. A CT scan revealed subarachnoid hemorrhage and SDH in both hemispheres with basal skull fracture and pneumocephalus (Fig. 3A), a grade III spleen laceration with contrast extravasation and perisplenic fluid collection (Fig. 3B), and multiple rib fractures with hemopneumothorax in the left hemithorax. Shortly after the imaging evaluation, hypotension gradually developed even though volume resuscitation and low-dose vasopressor infusion were continued. With his blood pressure at 48/26 mmHg and pulse rate at 89 bpm, Zone I REBOA using a RESCUE Balloon^TM was performed 55 minutes after arrival (Fig. 3C). After 11-mL balloon inflation, his blood pressure and pulse rate rose to 127/76 mmHg and 128 bpm, respectively. Since a poor outcome was expected due to severe brain edema, craniectomy was performed prior to laparotomy. Craniectomy revealed severe brain edema after hematoma removal and was completed with suspension of the crash laparotomy. Weaning from REBOA was completed in the intensive care unit about 1 hour after the operation and replaced with vasopressor infusion. The patient remained hemodynamically unstable despite high-dose vasopressor infusion and died 4 hours after the operation.

The injury severity scores of patients 1, 2, and 3 were 50, 38, and 43, respectively. The procedural timepoints with regards to REBOA and the clinical features of the three patients are shown in Table 1.